Services

Custom Synthesis

Vibrant offers reliable and high quality custom organic synthesis services for the chemical, pharmaceutical and biotechnology industries and to Universities and research institutions in ranging from milligram to kilogram quantities since 2006.  Our experienced and knowledgeable chemists have all worked for many years in the field of custom synthesis with extensive academic, and industrial backgrounds specialized in small organic molecules, natural products, modified nucleosides, heterocycles, kinase focused libraries, peptides and aminoacids.

Our experienced chemists develop safe, cost effective, and robust process for lead drug candidates, APIs, and intermediates. Vibrant provides economical manufacturing solution for bulk scale custom synthesis service. We have offshore manufacturing partners who have expertise in large-scale organic chemical manufacturing with very competitive pricing.

We offer following services:

·         Synthesis of reference standards, metabolites and impurities

·         Chiral synthesis and separation

·         Identification of novel synthetic route and optimization of chemical reactions

·         Trouble-shoot the process implementation for the initial batches

·         Identification of process impurities and study to control their formation

·         Preparation of key intermediates, scaffolds, building blocks and preparation of final target molecules

·         Wide range of palladium-catalyzed coupling reactions

·         Catalytic hydrogenation and pressure reactions

·         Bromination, Nitration, Sulfonylation, Friedel Crafts reactions, and Wittig reactions

·         Boronic acids and fluoroborates

·         Modified nucleosides and phosphoramidite synthesis

·         Prodrug synthesis, polymorph screening, and stability studies.

·         FTE or project-based services

·         Focused libraries for lead optimization

Medicinal Chemistry

Our highly trained chemists have many years of academic and industrial experience in medicinal chemistry and a proven record of accomplishment of producing active drug candidates in a variety of therapeutic areas including metabolic disorder, infectious disease, cardiovascular, inflammation and oncology that have reached various phases of clinical trials.  

If you have need for exploratory, collaborative R&D synthesis, Vibrant Pharma team can work closely with your chemists and biologists as collaborator or consultant to help you advance your drug discovery projects.

Our services include:

• FTE or project-based services

• Hit-to-Lead identification and optimization of leads

• Focused library synthesis for kinase, protein-protein, GPCR and other proposed targets